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Cesare Furlanello received his degree in Mathematics at the University of Padua, Italy, in 1986. He is at Fondazione Bruno Kessler (Centre for Scientific and Technological Research of Trento) since 1987, now a Senior Researcher. He is currently leader of the MPBA Project (previously the ITC-IRST Neural Networks for Complex Data Analysis Project, since 1995).
In general terms, he is a data scientist, with main research interests in the interdisciplinary applications of machine learning methods to biomedical and environmental data. He is active in the field of bioinformatics, developing methods and software solutions to find patterns in very high throughput molecular data (such as Next Generation Sequencing and microarrays). He also have years of experience with machine learning and data analysis for geoinformatics, aiming at creating a bridge (geo-bioinformatics) between molecular profiles and spatial data structures. He has designed and managed many collaborative studies with life science researchers, in which math and software infrastructures are integrated to discover patterns in high-throughput datasets. He was first Project manager at IRST for the National Bioelectronics Project (1991-94), and he is currently PI and project manager of research projects in which Predictive Models are applied to Biomedical and Environmental data, for a total of 58 funded projects since 1988. These studies combine statistical machine learning methods with new sw infrastructures for data collection, management and distribution of the resulting models: Predictive Health Platforms and Geoinformatics platforms are thus the final outcome. The most recent research is directed to applications in functional genomics, including the development of computational pipelines and a focus to the problems of scientific reproducibility.
Basic and applied studies have been developed at the MPBA group with colleagues in other institutions on molecular oncology, vector-borne disease mapping, wildlife epidemiology, traffic safety, landscape risk analysis. CF has actively contributed to computational aspects, supporting the development of open source geoinformatics (GIS GRASS, WebGIS) and high performance machine learning (mlpy). Since 2002, he has contributed to the development of predictive classification models and gene selection procedures for molecular diagnostics, in collaboration with national and international centres of excellence in molecular oncology. He is a bioinformatics PI collaborator of international consortia such as the SEQC/MAQC FDA initiative and the FANTOM5 project led by the RIKEN OMICS centre. He has been a PI for AIRC with the IFOM-FIRC institute. He is also a collaborator PI in several projects of the Mach Foundation (FEM) for computational biology (metagenomics) and environmental mapping (climate change and plant genomics)
Several of the systems realized in experimental studies are now data platforms in use as infrastructures by public agencies: IET, MITRIS (Trentino and Friuli-VG), UXB-TN (Trentino), FaunaTN and FaunaBL (Trentino and Belluno) are the largest. The spinoff company MPA Solutions is mantaining these systems and developing WebGIS technologies with predictive modeling functions.
CF was Scientific secretary of the GNCB-CNR school on Neural Networks for Signal Processing (Trento 1989) and organizer of other workshops on Applications of Machine Learning and Neural Networks. In September 2008, he was Local Conference Chair of the MGED11 International Workshop of the MGED Society (in its Advisory Board since 2007) and he is now in the Board of Directors of the FGED society. Lecturer on Neural Network and Statistics at Master School of Advanced Information Science of Salerno University. Chairman of Session Theory 1 at IEEE NNSP-95 Cambridge MA, 1995. Member of the Scientific Board of the Multiple Classifier Systems series of conferences. Invited participant in the Machine Learning and Neural Networks Program of the Newton Institute of Mathematical Science, Cambridge UK, 1998. Member of the Italian Neural Network Society (serving in its Scientific Board 1991-2005), of the International Association for Pattern Recognition.
Invited lectures (a selection): NATO-ASI school Learning with Ensemble models (Vietri 2002), the ECEM/EAML Conference (Bled 2004), at the Int. BCB-Workshop on Machine Learning in Bioinformatics (Oct. 2005, Berlin), Int. School "The analysis of patterns" (Nov. 2005, Erice), "Predictive modeling on spatio-temporal patterns" (April 2007, Univ. Bristol), and "Signature Stability Analysis" (Nov 2007, Silver Springs, FDA).
He has been supervisor of 30 graduate or postgraduate theses for the universities of Trento (Mathematics and Engineering), Milano, Bologna, and Torino, supervisor of Leonardo graduate placements, tutor of 8 ASI-CONAE fellows in 2003-2012. Currently a supervisor of internships for Master thesis in Mathematics, Information and Telecommunication Engineering for the University of Trento, as well as a tutor for post-doc fellowships. Courses held: 1998-2003: Lecturer on COMPUTATIONAL STATISTICS AND PREDICTIVE MODELS, Math MsC, Trento University, and 2004-06: Lecturer on "Statistical Machine Learning", a course for the International Graduate School in ICT, Trento University. He is currently a member of the PhD School in Biomolecular sciences of UniTN.
He is a founder of the WEBVALLEY project, the FBK summer course for dissemination of interdisciplinary scientific research. Since 2001, CF is responsible for the WebValley Scientific program, and a resident tutor for all the 12 editions of this event. Developing the culture of data with open source platforms (web scripting, geodatabases, webGIS, tools for data visualization, statistical analysis decision making) based on a challenging project is the theme of 3 fast-paced weeks, in which about 20 high schools students team up with senior and junior researchers. In 2012, for this activity CF has been listed as "one of the 50 persons that are changing the world" by Wired, Italian edition (at #42, as in the H Guide).
De Mariano, Marilena; Gallesio, Roberta; Chierici, Marco; Furlanello, Cesare; Conte, Massimo; Garaventa, Alberto; Croce, Michela; Ferrini, Silvano; Tonini, Gian Paolo; Longo, Luca,Identification of GALNT14 as a novel neuroblastoma predisposition gene,in «ONCOTARGET»,vol. 6,n. 28,2015, pp. 26335-46 -26346
Mina, Marco; Magi, Shigeyuki; Jurman, Giuseppe; Itoh, Masayoshi; Kawaji, Hideya; Lassmann, Timo; Arner, Erik; Forrest, Alistair R R; Carninci, Piero; Hayashizaki, Yoshihide; Daub, Carsten O; Okada-Hatakeyama, Mariko; Furlanello, Cesare,Promoter-level expression clustering identifies time development of transcriptional regulatory cascades initiated by ErbB receptors in breast cancer cells,in «SCIENTIFIC REPORTS»,vol. 5,2015, pp. 11999 -
Ceccarelli, Sara; Panera, Nadia; Mina, Marco; Gnani, Daniela; De Stefanis, Cristiano; Crudele, Annalisa; Rychlicki, Chiara; Petrini, Stefania; Bruscalupi, Giovannella; Agostinelli, Laura; Stronati, Laura; Cucchiara, Salvatore; Musso, Giovanni; Furlanello, Cesare; Svegliati-Baroni, Gianluca; Nobili, Valerio; Alisi, Anna,LPS-induced TNF-α factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease,in «ONCOTARGET»,vol. 6,n. 39,2015, pp. 41434-52 -
Diaz-Lacava, A N; Walier, M; Holler, D; Steffens, M; Gieger, C; Furlanello, C; Lamina, C; Wichmann, H E; Becker, T,Genetic Geostatistical Framework for Spatial Analysis of Fine-Scale Genetic Heterogeneity in Modern Populations: Results from the KORA Study,in «INTERNATIONAL JOURNAL OF GENOMICS»,vol. 2015,2015, pp. 693193 -15
Zhang, Wenqian; Yu, Ying; Hertwig, Falk; Thierry-Mieg, Jean; Zhang, Wenwei; Thierry-Mieg, Danielle; Wang, Jian; Furlanello, Cesare; Devanarayan, Viswanath; Cheng, Jie; Deng, Youping; Hero, Barbara; Hong, Huixiao; Jia, Meiwen; Li, Li; Lin, Simon M; Nikolsky, Yuri; Oberthuer, André; Qing, Tao; Su, Zhenqiang; Volland, Ruth; Wang, Charles; Wang, May D; Ai, Junmei; Albanese, Davide; Asgharzadeh, Shahab; Avigad, Smadar; Bao, Wenjun; Bessarabova, Marina; Brilliant, Murray H; Brors, Benedikt; Chierici, Marco; Chu, Tzu-Ming; Zhang, Jibin; Grundy, Richard G; He, Min Max; Hebbring, Scott; Kaufman, Howard L; Lababidi, Samir; Lancashire, Lee J; Li, Yan; Lu, Xin X; Luo, Heng; Ma, Xiwen; Ning, Baitang; Noguera, Rosa; Peifer, Martin; Phan, John H; Roels, Frederik; Rosswog, Carolina; Shao, Susan; Shen, Jie; Theissen, Jessica; Tonini, Gian Paolo; Vandesompele, Jo; Wu, Po-Yen; Xiao, Wenzhong; Xu, Joshua; Xu, Weihong; Xuan, Jiekun; Yang, Yong; Ye, Zhan; Dong, Zirui; Zhang, Ke K; Yin, Ye; Zhao, Chen; Zheng, Yuanting; Wolfinger, Russell D; Shi, Tieliu; Malkas, Linda H; Berthold, Frank; Wang, Jun; Tong, Weida; Shi, Leming; Peng, Zhiyu; Fischer, Matthias,Comparison of RNA-seq and microarray-based models for clinical endpoint prediction,in «GENOME BIOLOGY»,vol. 16,n. 1,2015, pp. 133 -
Mina, Marco; Boldrini, Renata; Citti, Arianna; Romania, Paolo; D'Alicandro, Valerio; De Ioris, Maretta; Castellano, Aurora; Furlanello, Cesare; Locatelli, Franco; Fruci, Doriana,Tumor-infiltrating T lymphocytes improve clinical outcome of therapy-resistant neuroblastoma,in «ONCOIMMUNOLOGY»,vol. 4,n. 9,2015, pp. e1019981 -
Kieran M. Tuohy; Paola Venuti; Simone Cuva; Cesare Furlanello; Mattia Gasperotti; Andrea Mancini; Florencia Ceppa; Duccio Cavalieri; Carlotta de Filippo; Urska Vrhovsek; Pedro Mena; Daniele Del Rio; Francesca Fava,Diet-Microbe Interactions in the Gut,2015, pp. 225 -245
Jurman, Giuseppe; Visintainer, Roberto; Filosi, Michele; Riccadonna, Samantha; Furlanello, Cesare,Data Science and Advanced Analytics (DSAA), 2015. 36678 2015. IEEE International Conference on,2015, pp. 1-10, (Data Science and Advanced Analytics (DSAA), 2015. 36678 2015. IEEE International Conference on,Paris,19-21 Oct. 2015)
M. Filosi; R. Visintainer; S. Riccadonna; G. Jurman; C. Furlanello,Stability Indicators in Network Reconstruction,in «PLOS ONE»,vol. 9,n. 2,2014, pp. e89815 -
Alistair R. R. Forrest; Hideya Kawaji; Michael Rehli; J. Kenneth Baillie; Michiel J. L. de Hoon; Vanja Haberle; Timo Lassmann; Ivan V. Kulakovskiy; Marina Lizio; Masayoshi Itoh; Robin Andersson; Christopher J. Mungall; Terrence F. Meehan; Sebastian Schmeier; Nicolas Bertin; Mette Jørgensen; Emmanuel Dimont; Erik Arner; Christian Schmidl; Ulf Schaefer; Yulia A. Medvedeva; Charles Plessy; Morana Vitezic; Jessica Severin; Colin A. Semple; Yuri Ishizu; Robert S. Young; Margherita Francescatto; Intikhab Alam; Davide Albanese; Gabriel M. Altschuler; Takahiro Arakawa; John A. C. Archer; Peter Arner; Magda Babina; Sarah Rennie; Piotr J. Balwierz; Anthony G. Beckhouse; Swati Pradhan-Bhatt; Judith A. Blake; Antje Blumenthal; Beatrice Bodega; Alessandro Bonetti; James Briggs; Frank Brombacher; A. Maxwell Burroughs; Andrea Califano; Carlo V. Cannistraci; Daniel Carbajo; Yun Chen; Marco Chierici; Yari Ciani; Hans C. Clevers; Emiliano Dalla; Carrie A. Davis; Michael Detmar; Alexander D. Diehl; Taeko Dohi; Finn Drabløs; Albert S. B. Edge; Matthias Edinger; Karl Ekwall; Mitsuhiro Endoh; Hideki Enomoto; Michela Fagiolini; Lynsey Fairbairn; Hai Fang; Mary C. Farach-Carson; Geoffrey J. Faulkner; Alexander V. Favorov; Malcolm E. Fisher; Martin C. Frith; Rie Fujita; Shiro Fukuda; Cesare Furlanello; Masaaki Furuno; Jun-ichi Furusawa; Teunis B. Geijtenbeek; Andrew P. Gibson; Thomas Gingeras; Daniel Goldowitz; Julian Gough; Sven Guhl; Reto Guler; Stefano Gustincich; Thomas J. Ha; Masahide Hamaguchi; Mitsuko Hara; Matthias Harbers; Jayson Harshbarger; Akira Hasegawa; Yuki Hasegawa; Takehiro Hashimoto; Meenhard Herlyn; Kelly J. Hitchens; Shannan J. Ho Sui; Oliver M. Hofmann; Ilka Hoof; Fumi Hori; Lukasz Huminiecki; Kei Iida; Tomokatsu Ikawa; Boris R. Jankovic; Hui Jia; Anagha Joshi; Giuseppe Jurman; Bogumil Kaczkowski; Chieko Kai; Kaoru Kaida; Ai Kaiho; Kazuhiro Kajiyama; Mutsumi Kanamori-Katayama; Artem S. Kasianov; Takeya Kasukawa; Shintaro Katayama; Sachi Kato; Shuji Kawaguchi; Hiroshi Kawamoto; Yuki I. Kawamura; Tsugumi Kawashima; Judith S. Kempfle; Tony J. Kenna; Juha Kere; Levon M. Khachigian; Toshio Kitamura; S. Peter Klinken; Alan J. Knox; Miki Kojima; Soichi Kojima; Naoto Kondo; Haruhiko Koseki; Shigeo Koyasu; Sarah Krampitz; Atsutaka Kubosaki; Andrew T. Kwon; Jeroen F. J. Laros; Weonju Lee; Andreas Lennartsson; Kang Li; Berit Lilje; Leonard Lipovich; Alan Mackay-sim; Ri-ichiroh Manabe; Jessica C. Mar; Benoit Marchand; Anthony Mathelier; Niklas Mejhert; Alison Meynert; Yosuke Mizuno; David A. de Lima Morais; Hiromasa Morikawa; Mitsuru Morimoto; Kazuyo Moro; Efthymios Motakis; Hozumi Motohashi; Christine L. Mummery; Mitsuyoshi Murata; Sayaka Nagao-Sato; Yutaka Nakachi; Fumio Nakahara; Toshiyuki Nakamura; Yukio Nakamura; Kenichi Nakazato; Erik van Nimwegen; Noriko Ninomiya; Hiromi Nishiyori; Shohei Noma; Tadasuke Nozaki; Soichi Ogishima; Naganari Ohkura; Hiroko Ohmiya; Hiroshi Ohno; Mitsuhiro Ohshima; Mariko Okada-Hatakeyama; Yasushi Okazaki; Valerio Orlando; Dmitry A. Ovchinnikov; Arnab Pain; Robert Passier; Margaret Patrikakis; Helena Persson; Silvano Piazza; James G. D. Prendergast; Owen J. L. Rackham; Jordan A. Ramilowski; Mamoon Rashid; Timothy Ravasi; Patrizia Rizzu; Marco Roncador; Sugata Roy; Morten B. Rye; Eri Saijyo; Antti Sajantila; Akiko Saka; Shimon Sakaguchi; Mizuho Sakai; Hiroki Sato; Hironori Satoh; Suzana Savvi; Alka Saxena; Claudio Schneider; Erik A. Schultes; Gundula G. Schulze-Tanzil; Anita Schwegmann; Thierry Sengstag; Guojun Sheng; Hisashi Shimoji; Yishai Shimoni; Jay W. Shin; Christophe Simon; Daisuke Sugiyama; Takaaki Sugiyama; Masanori Suzuki; Naoko Suzuki; Rolf K. Swoboda; Peter A. C. ’t Hoen; Michihira Tagami; Naoko Takahashi; Jun Takai; Hiroshi Tanaka; Hideki Tatsukawa; Zuotian Tatum; Mark Thompson; Hiroo Toyoda; Tetsuro Toyoda; Eivind Valen; Marc van de Wetering; Linda M. van den Berg; Roberto Verardo; Dipti Vijayan; Ilya E. Vorontsov; Wyeth W. Wasserman; Shoko Watanabe; Christine A. Wells; Louise N. Winteringham; Ernst Wolvetang; Emily J. Wood; Yoko Yamaguchi; Masayuki Yamamoto; Misako Yoneda; Yohei Yonekura; Shigehiro Yoshida; Susan E. Zabierowski; Peter G. Zhang; Xiaobei Zhao; Silvia Zucchelli; Kim M. Summers; Harukazu Suzuki; Carsten O. Daub; Jun Kawai; Peter Heutink; Winston Hide; Tom C. Freeman; Boris Lenhard; Vladimir B. Bajic; Martin S. Taylor; Vsevolod J. Makeev; Albin Sandelin; David A. Hume; Piero Carninci; Yoshihide Hayashizaki,A promoter-level mammalian expression atlas,in «NATURE»,vol. 507,2014, pp. 462 -470