Machine Learning, Bioinformatics and Geospatial Technologies

We develop predictive models on complex spatio-temporal patterns, integrating the different molecular biology levels, spatially explicit population models and landscape environmental analysis. We aim to create novel mathematical methods and ICT platforms connecting physiopathological patterns of disease with high dimensional data now available for Functional Genomics (e.g DNA microarrays, SNPs, proteomics, Deep Sequencing), with spatially epidemics simulation systems and geodatabases of environmental factors and socio-demographic data.

Our research is interdisciplinary. Since 1996, we have been working on biological and environmental data, porting novel Statistical Machine Learning Methods (classifiers and regression models) within Geographical Information Systems (GIS), with results in landscape epidemiology and environmental risk analysis. More recently, we started developing Individual Based Model (IBM) simulators of global pandemic scenarios (FLUMODCONT, EPIWORK). Since 2002, we also develop predictive machine learning methods for functional genomics: we design algorithms for predictive classification and profiling of high-throughput data, with implementation on standard workstations, computer clusters and in grid.

For our projects, we develop new software infrastructures (such as MITRIS) for data collection, management and analysis, supporting research and public agencies. We have created innovation in GIS (GRASS) and internet GIS (WebGIS) systems, and the spinoff company MPA Solutions in 2004. For high-throughput genomics data, we develop the Python/C machine learning package MLPY, several bioinformatics solutions, and we work for the integration of different genomics and patient data.

Finally, we actively promote the dissemination of interdisciplinary science with the WebValley Summer School Project, and by acting as a training lab for undergraduate and graduate students. We are proud to support projects of social interest that require visualizing and understanding data patterns such as the Intersos WebGIS for Humanitarian Response for Darfur and Tchad and the OECD Global Project on Measuring the Process of Societies. Since 2011, WebValley is international, with the participation of finalists of the INTEL ISEF Science Fair.



September 9, 2014

Nature Biotechnology
Focus on RNA sequencing quality control (SEQC)


We contributed in two papers with SEQC/MAQC-III Consortium:

A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
SEQC/MAQC-III Consortium

Nature Biotechnology 32, 903–914 (2014)

The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance
SEQC/MAQC-III Consortium

ature Biotechnology 32, 926–932 (2014)


March 27, 2014

FANTOM5 Promoterome

A promoter-level mammalian expression atlas

The FANTOM Consortium and the RIKEN PMI and CLST (DGT)

Nature, 507:462-470, 2014


FBK press release


July, 2013: 1 grant funded by Bruno Kessler Foundation (FBK) on the topic "Predictive networks methods for functional metagenomics"

The candidate will develop original research on the integration of machine learning and network medicine methods within a state-of-art bioinformatics framework for the quantitative analysis of microbial communities of clinical interest. In particular, network-based methods for functional metagenomics studies will be applied to Next Generation Sequencing (NGS).


EVENT: iDSDn2010 - Next-generation Sequencing for Biomedical Omics 2010 (Castel Ivano, 20-21 Sept 2010), with CiBIO UniTN and IST Genova.

PAPERS: August 2010, the MAQC Consortium papers are out: with a main paper on Nature Biotechnology and Special Issue on The Pharmacogenomics Journal: see


Special Website Section: ICT 4 Climate Change. (June 2010).

Other 2010 EVENTS:, "WPS and scientific computing for climate change: informal day" ENVIROCHANGE Workshop. Joint FBK & Cosbi "Informal Network Day" Workshop

PAPER: Paper and Editorial on February 2009 issue of Nature Genetics

Nature Genetics Cover

Repeatability of published microarray gene expression analyses

John P A Ioannidis, David B Allison, Catherine A Ball, Issa Coulibaly, Xiangqin Cui, Aedín C Culhane, Mario Falchi, Cesare Furlanello, Laurence Game, Giuseppe Jurman, Jon Mangion, Tapan Mehta, Michael Nitzberg, Grier P Page, Enrico Petretto & Vera van Noort





Le Nuove Frontiere della Biologia

Riva del Garda - Cortile della Rocca

Mercoledi' 3 Settembre 2008, ore 20:45